Nestled in the heart of the Ozarks, St. James, Missouri, has a rich history rooted in railroad expansion, viticulture, and a strong sense of community.

The town was originally established in the 1850s and was first known as Big Prairie. With the construction of the St. Louis–San Francisco Railway (Frisco) through the area in 1860, the town began to take shape and thrive.

It was soon renamed St. James in honor of Thomas James, a prominent early supporter of the region’s development and founder of the nearby Maramec Iron Works—one of the earliest ironworks west of the Mississippi.

St. James quickly became a hub for agriculture and industry, benefiting from its fertile soil, natural springs, and growing access to trade routes.

The area’s unique climate and terrain proved ideal for grape cultivation, leading to the establishment of vineyards and wineries as early as the 1870s.

This legacy continues today, with St. James recognized as part of Missouri’s wine country, home to some of the state’s most well-known wineries.

Two remarkable women helped shape the spirit and identity of St. James.

Lucy Wortham James, a philanthropist and descendant of Thomas James, dedicated her life and resources to the well-being of the community. Her generous donations led to the creation of the James Foundation, which continues to support local projects including the preservation of Maramec Spring Park—one of Missouri’s most treasured natural sites.

Another trailblazer, Mayme Ousley, made history in 1921 when she was elected mayor of St. James, becoming the first female mayor in Missouri. Her leadership and dedication to public service inspired generations and marked an important milestone in the state’s civic history.

Today, St. James remains a vibrant, welcoming town that honors its heritage while embracing progress. From its historic roots in iron and wine to its tradition of strong community leadership, St. James continues to grow with purpose and pride.