Historic Route 66

Discover Historic Route 66 in St. James, Missouri

Set along the legendary Route 66, St. James holds a blend of history, scenery, and genuine small-town hospitality, it’s a place that invites you to slow down and explore. Whether you’re driving the Mother Road or searching for memorable things to do in mid-Missouri, this is a stop worth making.

Top Route 66 Highlights

• One of Missouri’s favorite trout-fishing destinations just minutes from town

• Local shops, wineries, and dining right off the highway

• Easy access to outdoor beauty and historic sites

Nearby favorites include Maramec Spring Park and the historic Maramec Iron Works, plus local staples like Johnnie’s Bar and Grill, St. James Winery, Sybill’s Restaurant and Gift Shop, and Spencer Manor Winery, just to name a few.

Plan your stop. Explore more. Stay awhile.